Resistance to empirical antibiotics in urinary tract infections caused by Enterobacterales in the East of England.

Objectives: To characterize resistance rates in urinary tract infections caused by Enterobacterales to first- and second-line antibiotics.

Methods: Positive urine cultures examined by the Eastern Pathology Alliance network from September 2018 to September 2023 were retrospectively analysed. Enterobacterales from non-pregnant adults were included.

Clinical Research Network: JHCRN Infrastructure and Lessons Learned.

Clinical research studies are becoming increasingly complex resulting in compounded work burden and longer study cycle times, each fueling runaway costs. The impact of protocol complexity often results in inadequate recruitment and insufficient sample sizes, which challenges validity and generalizability. Understanding the need to provide an alternative model to engage researchers and sponsors and bringing clinical research opportunities to the broader community, clinical research networks (CRN) have been proposed and initiated in the United States and other parts of the world.

ESCARGOT: An AI Agent Leveraging Large Language Models, Dynamic Graph of Thoughts, and Biomedical Knowledge Graphs for Enhanced Reasoning.

Motivation: LLMs like GPT-4, despite their advancements, often produce hallucinations and struggle with integrating external knowledge effectively. While Retrieval-Augmented Generation (RAG) attempts to address this by incorporating external information, it faces significant challenges such as context length limitations and imprecise vector similarity search. ESCARGOT aims to overcome these issues by combining LLMs with a dynamic Graph of Thoughts and biomedical knowledge graphs, improving output reliability and reducing hallucinations.

In functionally aligned total knee arthroplasty, femoral component rotation follows the transepicondylar axis to achieve flexion balance.

Purpose: In functionally aligned (FA) total knee arthroplasty (TKA), femoral component rotation (FCR) is personalised to optimise flexion gap balance. As axial malalignment has been attributed to patellofemoral complications, this study assessed FA FCR in relation to the surgical transepicondylar axis (TEA) and early implant survivorship.

Methods: We analysed 446 robotic-assisted primary TKAs in 393 patients using FA with preresection gap balancing.

The Role of Race/Ethnicity on the Association between Neighborhood Deprivation and Breast Cancer Outcomes among Kentucky Breast Cancer Patients years 2010-2022.

Background: Kentucky is within the top five leading states for breast mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiation therapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky.

Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry (KCR) for breast cancer patients diagnosed between 2010 and 2017, with follow-up through December 31, 2022.