Publications by authors named "J O Lundberg"
Recovery and Recurrence From Major Depression in Adolescence and Adulthood.
Acta Psychiatr Scand
January 2025
Article Synopsis
- The study examined 5-year recurrence rates of first-episode major depressive disorder (MDD) in adolescents and adults, finding rates of 46.1% for adolescents and 49.0% for adults.
- The research analyzed a large cohort from the Stockholm MDD database, balancing various factors like sex and socioeconomic status to ensure accurate comparisons between the two age groups.
- Results indicated that there was no significant difference in recurrence likelihood or time to recurrence between adolescents and adults, highlighting the importance of effective relapse prevention strategies across all ages.
Article Synopsis
- The study investigates the link between rising autism-related disorder (ASD-R) diagnosis rates and decreasing major depressive disorder (MDD) rates in Swedish adolescents aged 15-19 from 2008 to 2022.
- Results show a significant inverse relationship, with higher ASD-R diagnoses correlating to lower MDD rates, particularly in males.
- While causal conclusions are limited due to the study's observational design, the findings suggest a need for more comprehensive research on the complex interplay between these disorders.
The prevalence of cardiovascular-kidney-metabolic (CKM) syndrome is increasing rapidly, and cardiovascular complications pose significant risks in individuals with kidney disease and metabolic dysfunction. Understanding the mechanisms of CKM disorders is crucial, as is the discovery of novel preventive treatments. This study aimed to examine the therapeutic effects of a specially formulated nitric oxide-enhancing food additive in a mouse model of CKM syndrome induced by unilateral nephrectomy (UNX) in combination with chronic Western diet (WD) feeding.
View Article and Find Full Text PDFPET analysis is conventionally performed as a two-stage process of quantification followed by analysis. We recently introduced SiMBA (Simultaneous Multifactor Bayesian Analysis), a hierarchical model that performs quantification and analysis for all brain regions of all individuals at once, and in so doing improves both the accuracy of parameter estimation as well as inferential efficiency. However until now, SiMBA has only been implemented for the two-tissue compartment model.
View Article and Find Full Text PDFThe aim of this study was to explore biological interaction and pathophysiology mechanisms in a new mouse model of cardiovascular-kidney-metabolic (CKM) syndrome, induced by chronic moderate renal failure in combination with consumption of a customized Western diet rich in carbohydrates, fat and salt. Male C57BL/6J mice were subjected to unilateral nephrectomy, fed a customized Western diet rich not only in sugar and fat but also in salt, and followed for 12 weeks or 20 weeks. Sham-operated mice on a standard chow served as healthy controls.
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