Laboratory testing improves diagnosis and treatment outcomes in primary health care facilities.

Objective: To determine if use of basic laboratory tests improves diagnosis and treatment outcomes in outpatients attending rural primary health care facilities.

Setting: Six rural health centres in Kenya.

Design: Cross-sectional study to observe change in diagnosis and treatment made by clinical officers after laboratory testing in outpatients attending six rural health centres in Kenya.

Reduced risk of transfusion-transmitted HIV in Kenya through centrally co-ordinated blood centres, stringent donor selection and effective p24 antigen-HIV antibody screening.

Background: Following a 1994 study showing a high rate of transfusion-associated HIV, Kenya implemented WHO blood safety recommendations including: organizing the Kenya National Blood Transfusion Service (NBTS), stringent blood donor selection, and universal screening with fourth-generation p24 antigen and HIV antibody assays. Here, we estimate the risk of transfusion-associated HIV transmission in Kenya resulting from NBTS laboratory error and consider the potential safety benefit of instituting pooled nucleic acid testing (NAT) to reduce window period transmission.

Methods: From November to December 2008 in one NBTS regional centre, and from March to June 2009 in all six NBTS regional centres, every third unit of blood screened negative for HIV by the national algorithm was selected.

Molecular genetic diversity of hepatitis B virus in Kenya.

Eight genotypes of hepatitis B virus (A-H) and subgenotypes have been recognized worldwide. However, there is limited information on prevalent genotypes in many countries in Africa. This study was undertaken to determine the hepatitis B virus (HBV) genotypes in Kenya.

Laboratory epidemiologist: skilled partner in field epidemiology and disease surveillance in Kenya.

Although for over 20 years the Field Epidemiology Training Programs (FETPs) have provided a model for building epidemiology capacity in Ministries of Health worldwide, the model does not address laboratory training and its integration with epidemiology. To overcome this, Kenya added a laboratory management component in 2004, creating the first field epidemiology and laboratory training program (FELTP) to train both medical and laboratory epidemiologists. Laboratory management and epidemiology candidates were recruited from among degree-holding scientists at the Ministry of Health and trained in both applied epidemiology and laboratory management using a combination of short courses and extensive field placements.