Publications by authors named "J Novo"
Article Synopsis
- COVID-19 led to a global pandemic in 2020, creating a need for efficient decision-making by medical staff with limited resources during healthcare emergencies.
- The study introduces an automated method that utilizes multimodal data fusion, combining clinical features and deep learning from chest X-ray images, to estimate the risks of hospitalization and mortality for COVID-19 patients.
- Results indicate high accuracy in risk assessment (AUC-ROC scores of 0.8452 and 0.8285 for hospitalization and mortality, respectively) and show that incorporating imaging features improves hospitalization risk evaluation, while clinical features are more critical for mortality, emphasizing the approach's potential to enhance clinical decision-making across various medical scenarios.
Background: Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely due to factors (including extracellular vesicles (EVs)) that exist in the bloodstream. Therefore, inspiration can be taken from aging to develop new strategies for the transient opening of the BBB for drug delivery to the brain.
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- Acute kidney injury (AKI) occurs in patients after endovascular therapy for acute ischemic stroke, impacting recovery and survival rates.
- A study involving 1150 patients revealed an AKI incidence of 6%, with risk factors including older age, longer treatment times, and lower kidney function.
- AKI significantly correlates with higher mortality rates, emphasizing the need for improved treatment strategies for at-risk patients.
Article Synopsis
- - Glaucoma is a major cause of irreversible blindness, and diagnosing it involves measuring retinal layer thickness, which can be complicated in patients with elongated, highly myopic eyes due to distortions in OCT scans.
- - The study presents a new method for accurately segmenting retinal layers, specifically designed for patients with high myopia, enabling better differentiation of glaucoma from simple myopia.
- - Findings reveal significant reductions in retinal thickness in specific sectors of glaucoma patients with high myopia compared to those with myopia alone, enhancing understanding of the disease's impact.
Entrustable professional activities (EPAs) have been implemented in various medical specialties, and the Pathology National EPA Working Group has piloted the implementation of four pathology EPAs. We recently published the development of EPAs within our surgical pathology rotation. Following a six-month pilot, a survey demonstrated that faculty and residents found the forms helpful and easy to use and easy to understand, and EPAs have been fully incorporated into our surgical pathology rotation.
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