Publications by authors named "J Nordqvist"
Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause.
Front Endocrinol (Lausanne)
September 2023
Article Synopsis
- The glycosylation of IgG is important for its interaction with immune cells, and estrogen levels can influence these processes, especially after menopause.
- Researchers aimed to investigate how estrogen regulates IgG glycosylation in postmenopausal conditions using ovariectomized mice treated with estrogen.
- The findings indicated that estrogen treatment enhanced certain glycosylation patterns on IgG without affecting overall glycoprotein sialylation, suggesting estrogen plays a role in modulating immune responses through its impact on IgG glycosylation.
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease more common in females, potentially linked to sex hormones, and the effects of a specific estrogen treatment (TSEC) on lupus-related organ damage remain unclear.
- In a study involving ovariectomized mice, researchers tested how TSEC and other estrogen treatments affected B-cell development and kidney/salivary gland disease manifestations.
- Results showed that TSEC did not worsen lupus symptoms in the mouse model and provided protection against bone loss, suggesting it could be a viable treatment option for osteoporosis and related symptoms in postmenopausal women with lupus.
Inflammation has a significant effect on bone remodeling and can result in bone loss via increased stimulation of osteoclasts. Activated immunoglobulins, especially autoantibodies, can increase osteoclastogenesis and are associated with pathological bone loss. Whether immunoglobulins and mature B lymphocytes are important for general bone architecture has not been completely determined.
View Article and Find Full Text PDFOsteoporosis is a common secondary complication in patients with systemic lupus erythematosus (SLE). Current osteoporosis treatment with bisphosphonates has some negative side effects and there is a lack of data regarding newer treatments options for SLE associated osteoporosis. The tissue-selective estrogen complex (TSEC) containing conjugated estrogens and the selective estrogen receptor modulator bazedoxifene (Bza) is approved for treatment of postmenopausal vasomotor symptoms and prevention of osteoporosis.
View Article and Find Full Text PDFBackground: The DASH 7 is a recently published activity-related 7-item short form of the disability of the arm, shoulder, and hand (DASH) questionnaire developed to assess shoulder function in patients with subacromial pain. Before implementation in both intervention studies and in clinical practice, it is essential to evaluate its responsiveness. The objective of this study was to determine the minimal important change (MIC) in the DASH 7 questionnaire for patients with subacromial pain after a 3 months exercise intervention in a primary care context.
View Article and Find Full Text PDF