Publications by authors named "J Nolan"
Background: Lipoprotein(a) [Lp(a)] is a low-density lipoprotein variant with atherogenic, thrombogenic, and pro-inflammatory properties that may have numerous pathologic effects, including dyslipidemia. Screening for Lp(a) is clinically significant, due to its causal role in atherosclerotic cardiovascular disease (ASCVD). Among clinicians, however, there remains a general lack of both clinical awareness of Lp(a) and adequate tools to track Lp(a) testing in patients.
View Article and Find Full Text PDFBackground: The NHS Jewish BRCA Testing Programme is offering germline and genetic testing to people with ≥1 Jewish grandparent. Who have an increased likelihood of having an Ashkenazi Jewish (AJ) founder germline pathogenic variant (gPV) compared with the general population.Testing is offered via a self-referral, home-based saliva sampling pathway, supported by a genetic counsellor telephone helpline.
View Article and Find Full Text PDFArticle Synopsis
- The eighth annual summary from the International Liaison Committee on Resuscitation (ILCOR) focuses on the latest findings in cardiopulmonary resuscitation (CPR) and emergency cardiovascular care, building on a comprehensive review from 2020.
- This summary is based on the evaluation of recent resuscitation evidence by experts from six different ILCOR task forces, who utilized specific criteria to assess the quality of evidence and reached consensus treatment recommendations.
- The document also identifies key areas where more research is needed, sharing insights into the task forces’ discussions through sections like Justification and Evidence-to-Decision Framework Highlights.
Article Synopsis
- Percutaneous coronary intervention (PCI) for stable angina in the left main coronary artery has increased, with a study examining outcomes between men and women based on data from the UK's national PCI registry (2006-2022).
- The study found that while women undergoing LMCA PCI were older and had fewer comorbid conditions, they experienced higher mortality rates and major bleeding events compared to men, with significant statistical differences in these outcomes.
- The authors suggest that a sex-specific approach to treatment, taking into account factors like age and imaging techniques, could help improve the health outcomes for female patients undergoing this procedure.