Publications by authors named "J Nishio"

Altered gut microbiota is linked to systemic lupus erythematosus (SLE), but its association with disease development, disease activity, and post-intervention changes remains unclear. We compared new-onset SLE (NOSLE, n = 25), SLE in remission (RemSLE, n = 30), and healthy controls (HC, n = 30) cross-sectionally and conducted the first longitudinal analysis of NOSLE patients (n = 22) from pre-intervention to remission over 12 months. Significant β-diversity differences were observed in both NOSLE and RemSLE compared to HC, but not between NOSLE and RemSLE.

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  • The Wnt/β-catenin signaling pathway is implicated in glucocorticoid-induced osteoporosis (GIOP), and previous studies suggested that inhibiting sclerostin could provide a treatment option.
  • The study aimed to evaluate the effectiveness of romosozumab (ROMO), compared to denosumab (DMAb) and bisphosphonates (BP), in increasing bone mineral density (BMD) in patients with rheumatic diseases undergoing glucocorticoid therapy.
  • Results showed that ROMO significantly improved lumbar spine BMD after 12 months, indicating that it is a promising treatment for patients with GIOP.
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Background/aim: Desmoplastic fibroblastoma, also known as collagenous fibroma, is a rare benign mesenchymal neoplasm that primarily arises in the subcutaneous tissue of upper extremities and limb girdles. The knee is an uncommon location for desmoplastic fibroblastoma. Recent studies have demonstrated the presence of immunoreactivity for FOS like 1 (FOSL1) and rearrangements of FOSL1.

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  • Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare fat tumor that usually appears in the skin layer of middle-aged adults' limbs, potentially returning after incomplete removal but not spreading to distant areas.
  • Histologically resembling spindle cell/pleomorphic lipoma, ASCPLT shows a mix of abnormal cells, including atypical spindle cells and multinucleated giant cells, and can sometimes undergo a change to a more aggressive form, although its significance is still unclear.
  • The primary treatment is complete surgical removal, and the review covers the tumor's clinical features, pathology, and ongoing discussions about differentiating it from similar tumors.
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