Publications by authors named "J Nietfeld"
Purpose: We investigated effects of an adaptive telehealth coaching model on caregiver implementation of enhanced milieu teaching (EMT) with newly diagnosed toddlers with autism.
Method: Three caregiver-child dyads participated in a multiple-baseline-across-behaviors, single-case design. Caregivers were taught EMT via telehealth using the teach-model-coach-review approach.
Activation of neurokinin-III receptors modulates human atrial TASK-1 currents.
J Mol Cell Cardiol
November 2023
Rationale: The neurokinin-III receptor was recently shown to regulate atrial cardiomyocyte excitability by inhibiting atrial background potassium currents. TASK-1 (hK3.1) two-pore-domain potassium channels, which are expressed atrial-specifically in the human heart, contribute significantly to atrial background potassium currents.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the effects of a hybrid intervention combining Enhanced Milieu Teaching (EMT) and JASPER on the social communication and language outcomes of young autistic children, involving 120 caregiver-child pairs.
- Results showed that while caregivers from the intervention group utilized strategies more effectively, there were no significant improvements in child outcomes compared to a control group after the intervention period or at a follow-up.
- The findings suggest that despite enhanced caregiver strategy use, the specific intervention did not lead to measurable benefits for children's social communication and language skills, indicating a need for further research in this area.
Aims: Non-vitamin K antagonist oral anticoagulants (NOACs) are widely used in the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF). The efficacy of NOACs has been attributed in part to pleiotropic effects that are mediated through effects on thrombin, factor Xa, and their respective receptors. Direct pharmacological effects of NOACs and cardiac ion channels have not been addressed to date.
View Article and Find Full Text PDFBackground The tandem of P domains in a weak inward rectifying K+ channel (TWIK)-related acid-sensitive K channel (TASK-1; hK3.1) two-pore-domain potassium channel was recently shown to regulate the atrial action potential duration. In the human heart, TASK-1 channels are specifically expressed in the atria.
View Article and Find Full Text PDF