Publications by authors named "J Nicolas Pico"

Article Synopsis
  • Monoterpenoid biosynthesis in grape berries is linked to the accumulation of hexoses during ripening and is influenced by environmental factors like sunlight.
  • A study was conducted with 'Riesling' vines using girdling to limit nutrient flow and light-exclusion bags to reduce sunlight, revealing that girdling decreased photosynthesis and certain compound levels, while light exclusion reduced monoterpenoid levels.
  • Ultimately, while light exposure was crucial for the production of free monoterpenoids, girdling did not affect their total concentration, indicating that monoterpenoid synthesis is more influenced by light than by grape maturity or sugar levels.
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Article Synopsis
  • This study examines the feasibility and safety of using ultrasound (US) guidance for treating septic arthritis in children, comparing it to traditional fluoroscopic guidance.
  • It involved 67 children under various treatments (arthrocentesis or arthrotomy) and monitored them for at least two years, finding no significant differences in hospital stay or clinical outcomes between the two methods.
  • Ultimately, the results suggest that US guidance is a safe alternative to fluoroscopy for such procedures, as it avoids radiation exposure and helps visualize structures not visible on X-rays.
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Legume proteins can be induced to form amyloid-like fibrils upon heating at low pH, with the exact conditions greatly impacting the fibril characteristics. The protein extraction method may also impact the resulting fibrils, although this effect has not been carefully examined. Here, the fibrillization of lentil protein prepared using various extraction methods and the corresponding fibril morphology were characterized.

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N-Hydroxypipecolic acid (NHP) is a signaling molecule crucial for systemic acquired resistance (SAR), a systemic immune response in plants that provides long-lasting and broad-spectrum protection against secondary pathogen infections. To identify negative regulators of NHP biosynthesis, we performed a forward genetic screen to search for mutants with elevated expression of the NHP biosynthesis gene FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1). Analysis of two constitutive expression of FMO1 (cef) and one induced expression of FMO1 (ief) mutants revealed that the AIPP3-PHD2-CPL2 protein complex, which is involved in the recognition of the histone modification H3K27me3 and transcriptional repression, contributes to the negative regulation of FMO1 expression and NHP biosynthesis.

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