Thyroid function, autoimmunity, thyroid volume, and metabolic profile in people with Hashimoto thyroiditis.

Background: Hashimoto's thyroiditis (HT) is associated with high cardiovascular risk. Thyroid volume has a notable dispersion of values in these patients. This study aims to clarify the association between thyroid antibodies, thyroid morphology, insulin resistance, and lipid profile in patients with HT.

Randomized double-blind study on safety and tolerability of TP-102 phage cocktail in patients with infected and non-infected diabetic foot ulcers.

Background: Phage therapy offers a promising alternative for treating serious infections, including diabetic foot ulcers (DFUs), through the lytic action of phages. This randomized double-blind study was conducted to evaluate the safety and tolerability of the TP-102 bacteriophage cocktail in patients with DFUs non-infected and infected with Staphylococcus aureus, Pseudomonas aeruginosa, and/or Acinetobacter baumannii.

Methods: Nineteen participants with DFUs were randomized after susceptibility testing.

Dermatopathological findings of Bothrops atrox snakebites: A case series in the Brazilian Amazon.

Background: Bothrops venom consists primarily of metalloproteinase and phospholipase A2 toxins, which are responsible for the acute inflammatory, coagulant and hemorrhagic action following snakebite. The local effects of snakebite envenomation by Bothrops species are particularly prevalent yet poorly studied, but include pain, edema, erythema, blistering, bleeding, and ecchymosis.

Methods And Findings: In this study, we describe the dermatopathological findings observed in a series of 22 patients diagnosed with Bothrops envenomation treated in a tertiary hospital of Manaus, in the Brazilian Amazon.

The Pillars Concept: An Approach for Managing Hypertrophic Concha in Otoplasty.

Prominent ear deformities often result from a combination of hypertrophic conchal cartilage and an underdeveloped antihelical fold. Traditional otoplasty techniques, such as antihelical folding sutures and conchal setback maneuvers, may introduce tension and risk of relapse, leading to suboptimal aesthetic outcomes. The PILLARS CONCEPT: represents an alternative surgical approach specifically designed to address hypertrophic concha, ensuring stable and natural results.

Educational technology to empower patients as participants in their care.

Objectives: to build and validate an educational technology to empower patients as participants in their own care.

Methods: methodological study to develop an educational technology based on the elaboration, validation, and evaluation that were carried out in five stages at a teaching hospital in Amazonas. The study was carried out from 2019 to 2022, with the participation of 19 judges specialized in patient safety and 72 patients admitted to the hospital's medical and surgical clinics, the study setting.