Publications by authors named "J Neumeyer"
Article Synopsis
- Ischaemic diseases like critical limb ischaemia and heart attacks affect millions and endothelial cell (EC) transplants show promise in treatment but require support from other cells, complicating their use.
- This study found that mesenchymal stromal cells (MSCs) help ECs by transferring mitochondria via tunneling nanotubes, which is crucial for EC survival and function.
- Researchers developed a method to transplant mitochondria directly into ECs, enhancing their energy levels and promoting vessel formation without MSCs, while discovering that this process involves autophagy and the PINK1-Parkin pathway.
The dopamine D agonist MCL-524 is selective for the D receptor in the high-affinity state (D), and, therefore, the PET analogue, [F]MCL-524, may facilitate the elucidation of the role of D in disorders such as schizophrenia. However, the previously reported synthesis of [F]MCL-524 proved difficult to replicate and was lacking experimental details. We therefore developed a new synthesis of [F]MCL-524 using a "non-anhydrous, minimally basic" (NAMB) approach.
View Article and Find Full Text PDFThe dopamine D receptor exists in two different states, D and D; the former is the functional form of the D receptor and associates with intracellular G-proteins. The D agonist [H]MCL-536 has high affinity for the D receptor ( 0.8 nM) and potently displaces the binding of (-(-)---propylnorapomorphine (NPA; 0.
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- - The search for endothelial cells (ECs) for regenerative medicine highlights human blood-derived endothelial colony-forming cells (ECFCs) as a promising resource due to their ability to form blood vessels and easy retrieval from blood.
- - ECFCs provide significant support to human-derived heart cells (iCMs) by enhancing their survival and integration in cardiac settings through the release of the growth factor neuregulin-1 (NRG1).
- - Unlike mature ECs, ECFCs' unique ability to produce and release NRG1 helps protect iCMs from drug-induced damage, suggesting ECFCs are particularly valuable for cardiovascular therapies.
Human induced pluripotent stem cell (h-iPSC)-derived endothelial cells (h-iECs) have become a valuable tool in regenerative medicine. However, current differentiation protocols remain inefficient and lack reliability. Here, we describe a method for rapid, consistent, and highly efficient generation of h-iECs.
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