The border region between Austria, the Czech Republic, and Germany harbors the most south-western occurrence of moose in continental Europe. The population originated in Poland, where moose survived, immigrated from former Soviet Union or were reintroduced after the Second World War expanded west- and southwards. In recent years, the distribution of the nonetheless small Central European population seems to have declined, necessitating an evaluation of its current status.
View Article and Find Full Text PDFThe chromosome 16p13 region has been associated with several autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). CLEC16A has been reported as the most likely candidate gene in the region, since it contains the most disease-associated single-nucleotide polymorphisms (SNPs), as well as an imunoreceptor tyrosine-based activation motif. However, here we report that intron 19 of CLEC16A, containing the most autoimmune disease-associated SNPs, appears to behave as a regulatory sequence, affecting the expression of a neighbouring gene, DEXI.
View Article and Find Full Text PDFTetrakis(trimethylsilyl)tetrahedrane 3 has been synthesized upon irradiation of tetrakis(trimethylsilyl)cyclobutadiene 8, which can be prepared either by thermal nitrogen elimination from trimethylsilyl[1,2,3-tris(trimethylsilyl)-2-cycloprop-1-enyl]diazomethane 7 or by mild oxidation of cyclobutadiene dianion 9 with 1,2-dibromoethane. The structural characterization of tetrahedrane 3 has been achieved by X-ray crystallography. The surprising thermal stability of 3 - which is stable up to 300 degrees C - is discussed.
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