Detection of second malignancies during long-term follow-up of testicular cancer survivors.

Background: Second cancers are an important cause of mortality and morbidity in long-term survivors of testicular germ cell tumors (TGCTs). Studies on the impact of follow-up for the first tumor on the outcome of second malignancies are lacking. The aim of this study was to study the details of diagnosis of second cancers and the role of focused oncology follow-up.

[The effect of thrombocytapheresis on hematologic, biochemical and immunologic indicators].

The authors investigated in 33 separate donors the influence of thrombocytapheresis on haematological, biochemical and some immunological parameters. The paired t-test revealed a statistically significant increase of values of total proteins, aspartate aminotransferase, immunoglobulin A, alpha 1 antitrypsin, transferrin and the C4 component of complement seven days after apheresis and a significant increase of thrombocyte, total protein, alkaline phosphatase, immunoglobulin A, orosomucoid, and transferrin levels two weeks after apheresis. A significant decrease of haemoglobin values was recorded 7 and 14 days after apheresis.

Intermittent-flow versus continuous-flow mononuclear cell apheresis.

An intermittent-flow (Haemonetics V-50) and a continuous-flow (Fenwall CS-3000) blood cell separator were compared regarding mononuclear cell (MNC) collection. 17 evaluable V-50 and 24 CS-3000 aphereses were performed on healthy donors. No significant difference was found in MNC yield (median 6.

Blood count changes due to mononuclear cell apheresis.

Complete blood count and CFU-GM count of 41 healthy donors was determined immediately before and immediately after mononuclear cell (MNC) apheresis. Red blood cell count dropped from a mean of 5.2 to 4.