Publications by authors named "J Neo"
Article Synopsis
- * Evidence shows that the invasion process involves manipulating RBC calcium signaling, particularly through the interaction between RH5 and basigin, which leads to increased cAMP and calcium influx in RBCs.
- * The research highlights a conserved signaling pathway in host RBCs critical for parasite invasion and suggests new targets for therapeutic interventions against merozoite invasion.
Background: There is limited evidence on the economic burden of depression among the older population in Singapore.
Objective: We aim to evaluate the impact of depression on healthcare expenditure and productivity loss among older adults with chronic diseases in Singapore.
Methods: Using the data from the Well-being of the Singapore Elderly study (WiSE), a 2011 national representative survey of older adults aged 60 years and above, 2510 respondents were included in this study.
Objective: To assess the feasibility and safety of conducting robot-mediated impairment training (RMIT) and robot-mediated task-specific training (RMTT). The device deployed is the Optimo Regen (OR), capable of delivering both impairment-oriented training and task-specific training.
Methods: This was a single-centre, randomized, single-blinded, two-arm, parallel group, controlled trial.
Article Synopsis
- The study aimed to evaluate the effectiveness of adding metastasis-directed therapy (MDT) to camrelizumab in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M-NPC).
- A total of 39 patients participated, with no significant difference in the objective response rate (ORR) of unirradiated lesions between the Cam alone and Cam+MDT groups, despite a higher disease control rate in the latter.
- While overall survival was better for patients with more lesions in the Cam+MDT group, adverse events were similar between both treatments, indicating no substantial safety concerns.
Article Synopsis
- - This study evaluated the effectiveness of various liver stiffness measurement (LSM) scores, including AGILE3 + and AGILE4, in predicting liver-related events in patients with nonalcoholic fatty liver disease (NAFLD), particularly focusing on those with diabetes and obesity.
- - Data was analyzed from 1903 adult NAFLD patients who underwent vibration-controlled transient elastography (VCTE) over seven years, with a total of 25 liver-related events recorded.
- - Results showed that AGILE3 + and AGILE4 scores significantly outperformed LSM and FAST scores in predicting liver-related events, especially in individuals with diabetes and obesity, highlighting their potential for better risk stratification in