The genus is a phialidic, dematiaceous hyphomycete known for its intriguing morphology and turbulent taxonomic history. This polyphasic study represents a new, comprehensive view on the taxonomy, systematics, and biogeography of and its relatives. Phylogenetic analyses of three nuclear loci confirmed that is polyphyletic.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is a major contributor to the worldwide cancer burden. Recent studies on HCC have demonstrated dramatic alterations in expression of several cytochrome P450 (CYP) family members that play a crucial role in biotransformation of many drugs and other xenobiotics; however, the mechanisms responsible for their deregulation remain unclear.
Methods: We investigated a potential involvement of miRNAs in downregulation of expression of CYPs observed in HCC tumors.