Publications by authors named "J Necpal"
Article Synopsis
- The three clap test (TCT) is a quick bedside assessment that can reveal the applause sign (AS), which is characterized by patients clapping more than three times when asked to clap just three times.
- The AS helps distinguish between various neurological conditions, including progressive supranuclear palsy (PSP) and Parkinson's disease (PD), but can also appear in other conditions like Alzheimer's disease and frontotemporal dementia (FTD).
- The TCT can reveal additional behaviors, such as the non-applause sign linked to apathy in FTD and the jumping the gun sign indicating impulsivity in PSP, highlighting its value in clinical practice for assessing cognitive functions and behaviors.
Aim Of Study: To determine whether a high dose of levodopa-carbidopa intestinal gel (LCIG), expressed as levodopa equivalent daily dose (LE daily dose), is a risk factor for acute polyneuropathy in patients treated with LCIG.
Clinical Rationale For Study: Treatment with LCIG is an effective device-assisted therapy in the advanced stages of Parkinson's Disease (PD). Polyneuropathy is a well-known complication of PD treatment.
Article Synopsis
- - This study examines the link between rare variants in the cullin-3 ubiquitin ligase (CUL3) gene and neurodevelopmental disorders (NDDs), gathering data from multiple centers to explore genetic mutations and their clinical impacts.
- - Researchers identified 37 individuals with CUL3 variants, most of which result in loss-of-function (LoF), leading to intellectual disabilities and possibly autistic traits; specific mechanisms affecting protein stability were also investigated.
- - The findings enhance the understanding of NDDs associated with CUL3 mutations, suggesting that LoF variants are the main cause, which could help inform future diagnostics and treatment strategies.
Article Synopsis
- - The review examines how the antisaccadic task helps understand inhibitory processes in various basal ganglia disorders, like Parkinson's disease and Tourette syndrome, highlighting different saccadic profiles among them.
- - It focuses on two key inhibitory mechanisms: one that quickly suppresses strong responses (global, pre-emptive inhibition) and another that takes longer to inhibit specific responses (slower, selective response inhibition).
- - The antisaccadic task is useful in clinical settings for diagnosis and treatment monitoring, and future improvements should include standardizing eye-tracking methods and combining this data with other indicators of disease.