Publications by authors named "J Nealon"
Background: Influenza can be associated with nonrespiratory disease presentation, but these are less well documented due to the lack of routine testing for influenza in the healthcare system, especially if patients do not present with influenza-like illness (ILI). We aimed to measure the proportion of influenza cases seeking care at emergency department (ED) for a nontraumatic cause, to describe their clinical presentation and their ED-discharge diagnosis.
Methods: The study was conducted at seven hospitals in France, Spain, Italy and Germany during the 2019-20 influenza season, for a period of 10 weeks.
Time of day for vaccination, outcomes, and relative effectiveness of high-dose vs. standard-dose quadrivalent influenza vaccine: A post hoc analysis of the DANFLU-1 randomized clinical trial.
J Infect
November 2024
Article Synopsis
- - The study aimed to examine how the timing of influenza vaccinations (morning vs. later in the day) affects the immune response and overall health outcomes, particularly in a large trial comparing high-dose and standard-dose influenza vaccines.
- - Researchers analyzed data from 12,477 participants and found that earlier vaccinations were linked to fewer hospitalizations for respiratory issues, regardless of the vaccine dosage, with statistically significant results.
- - Although both high-dose and standard-dose vaccines showed similar effectiveness regardless of vaccination timing, the findings suggest that getting vaccinated earlier in the day could still be beneficial, warranting further investigation.
Influenza vaccination reduces the risk of adverse outcomes in patients with cardiovascular disease (CVD). We sought to evaluate whether the presence of CVD modified the relative effectiveness of high-dose (QIV-HD) vs. standard-dose (QIV-SD) quadrivalent influenza vaccine in this prespecified analysis of the DANFLU-1 trial.
View Article and Find Full Text PDFPrior infection with SARS-CoV-2 can provide protection against infection and severe COVID-19. We aimed to determine the impact of preexisting immunity on vaccine effectiveness (VE) estimates. We systematically reviewed and meta-analyzed 66 test-negative design studies that examined VE against infection or severe disease (hospitalization, intensive care unit admission, or death) for primary vaccination series.
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