Publications by authors named "J Nazaruk"
Cancer of the corpus uteri and cervix uteri, collectively ranks second among new cancer cases in women after breast cancer. Therefore, investigation of new anticancer agents and identifying new molecular targets presents a challenge to improve effectiveness of chemotherapy. In this study, antiproliferative activity of flavonoids derived from the buds of silver birch and downy birch was evaluated in endometrial cancer Ishikawa cells and cervical cancer HeLa cells.
View Article and Find Full Text PDFFlavonoids are bioactive secondary metabolites of plants, which exert anti-cancer effects. However, metabolism in enterocytes and the liver can influence the biological activity of flavonoids contained in the diet. Therefore, results from in vitro studies on cancer cells from the digestive tract and liver may reflect the real effects in the human body.
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- The study focuses on low-molecular-weight metabolites found in downy birch buds and their role in protecting the plant from stress.
- Using GC-MS, researchers identified 640 compounds, 314 of which were previously unrecognized in these buds.
- The main components discovered included sesquiterpenoids and flavonoids, known for their strong biological activity, suggesting they help defend the buds against various environmental stressors.
Article Synopsis
- - The study examined the effects of three specific compounds isolated from downy birch buds on the viability of six human cancer cell lines, using a method called MTT assay to measure cell survival.
- - Results showed that while one compound had general toxicity, the other two were specifically harmful to colon and stomach cancer cells, with a greater effect than the first compound.
- - The compounds induced apoptosis (programmed cell death) through both extrinsic and intrinsic pathways, with the findings suggesting that these triterpene acids could have potential as anticancer agents.
Purpose: In aging skin and some skin disorders, components of skin extracellular matrix (ECM) are disturbed and therefore research to find skin drugs is important. Evaluation of anethole impact on collagen, GAGs and MMP-2 in human skin fibroblasts was the aim of this study.
Materials And Methods: For collagen assay the Sircol dye, 5-[H]proline and real time-PCR were used.