Publications by authors named "J Nardi"
The consumption of hormone-derived medicines, such as levonorgestrel (LNG), is increasing worldwide, and its discharge into the environment reaches non-target organisms. In our previous study, we exposed the parental generation of zebrafish to environmentally relevant concentrations of LNG during the developmental phase. Subsequently, they had grown in a tank with clean water until adulthood.
View Article and Find Full Text PDFNumerous chemical compounds are found in aquatic environments; among them are pesticides. Pesticides are widely used worldwide, and this use has progressively increased in recent decades, resulting in the accumulation of potentially toxic compounds in surface waters. Dimethylamine-based herbicides (DBH) and imidacloprid-based insecticides (IBI) have low soil absorption and high water solubility, facilitating the arrival of these compounds in aquatic environments.
View Article and Find Full Text PDFArticle Synopsis
- - Methylphenidate (MPH) is a stimulant commonly prescribed for ADHD, but there are concerns about misdiagnosing ADHD in children, resulting in many neurotypical kids being exposed to MPH during crucial developmental stages.
- - A study was conducted using zebrafish, exposing them to therapeutic levels of MPH during their juvenile period, and later assessing their behavior as adults.
- - The findings revealed that childhood exposure to MPH led to lasting changes in behavior, such as increased anxiety and hyperactivity, indicating that inappropriate use of MPH in youth could have long-term effects on neurobehavioral development.
Phytoestrogens, such as isoflavones, are bioactive compounds found in plants with defense and protection functions. In the human body, they simulate the behavior of the hormone estradiol and can modulate the function of the male hypothalamic-pituitary-gonadal axis. This study aims to describe the effects of genistein on sperm quality of Wistar rats (male/adult) after a short oral administration protocol (50 mg/day, for 5 days), focusing on mitochondrial function.
View Article and Find Full Text PDFBackground: Hospitals expanded critical care capacity during the COVID-19 pandemic by treating COVID-19 patients with high-flow nasal cannula oxygen therapy (HFNC) in non-traditional settings, including general internal medicine (GIM) wards. The impact of this practice on intensive care unit (ICU) capacity is unknown.
Objective: To describe how our hospital operationalized the use of HFNC on GIM wards, assess its impact on ICU capacity, and examine the characteristics and outcomes of treated patients.