Tracking Response and Resistance in Acute Myeloid Leukemia through Single-Cell DNA Sequencing Helps Uncover New Therapeutic Targets.

Acute myeloid leukemia (AML) is an aggressive hematologic neoplasia with a complex polyclonal architecture. Among driver lesions, those involving the gene represent the most frequent mutations identified at diagnosis. The development of tyrosine kinase inhibitors (TKIs) has improved the clinical outcomes of -mutated patients (Pt).

A Pericardium Bovine Matrix Pocket in DTI Prepectoral Breast Reconstruction.

Breast reconstructive surgery has evolved significantly over the years. One of the recent advancements is the use of prepectoral implants in combination with synthetic and biological material as a natural and effective coverage. To date, there is little published data on breast reconstruction using acellular bovine pericardium matrix and most concern submuscular breast reconstruction.

A Novel Approach to Raman Distributed Temperature-Sensing System for Short-Range Applications.

A novel approach to the development of Distributed Temperature-Sensing (DTS) systems based on Raman Scattering in Multimode optical fibers operating at around 800 nm is presented, focusing on applications requiring temperature profile measurement in the range of a few hundreds of meters. In contrast to the standard Raman DTS systems, which aim to shorten the pulse space width as much as possible to improve the precision of measurement, the novel approach studied in this work is based on the use of pulses with a space width that is approximately equal to the distance covered by the fiber under test. The proposed technique relies on numerical post-processing to obtain the temperature profile measurement with a precision of about ±3 °C and a spatial resolution of 8 m, due to the transaction phases of the optical pulses.