Publications by authors named "J Nally"
The genus comprises unique atypical spirochete bacteria that includes the etiological agent of leptospirosis, a globally important zoonosis. Biofilms are microecosystems composed of microorganisms embedded in a self-produced matrix that offers protection against hostile factors. Leptospires form biofilms in rice fields and unsanitary urban areas, and while colonizing rodent kidneys.
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- The study focuses on non-Hardjo isolates of leptospirosis bacteria from human patients in Sri Lanka, revealing their complete genomes, which are less decayed compared to previously analyzed strains.
- The seven isolates, classified as a novel serovar, showed a lower number of pseudogenes and insertion sequences than earlier Hardjo genomes, indicating a potentially more functional genetic makeup.
- Findings suggest these Sri Lankan isolates exhibit unique pathogenic traits, including an increased number of specific virulence factor proteins, indicating a need for further research to understand leptospirosis mechanisms.
Introduction: Recent technological advancements allowed the development of engaging technological tools. Using ASN funding from the ASN, we developed a 3D Virtual Reality (VR) physiology course entitled DiAL-Neph (Diuretic Action and eLectrolyte transport in the Nephron). We hereby present its evaluation.
View Article and Find Full Text PDFLeptospirosis, caused by pathogenic bacteria from the genus , is a global zoonosis responsible for more than one million human cases and 60,000 deaths annually. The disease also affects many domestic animal species. Historically, genetic manipulation of has been difficult to perform, resulting in limited knowledge on pathogenic mechanisms of disease and the identification of virulence factors.
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- - Leptospirosis, a disease caused by bacteria prevalent mostly in tropical areas, is transmitted through contact with infected rat urine or contaminated environments, with brown rats being key urban reservoirs.
- - A study conducted in Boston from 2016-2022 involved analyzing DNA from 328 rat kidney samples, revealing that 59 rats were positive for leptospirosis and indicating significant genetic structure and limited dispersal among rat populations.
- - The researchers discovered distinct genetic clades of the bacteria linked to specific rat groups, suggesting that rat movement influences the spread of leptospirosis, and indicated a connection between the disease in humans and urban rat populations based on genomic analysis.