Publications by authors named "J Nakamichi"
[Changes in the residence of elderly people after hospitalization in the Integrated Community Care Ward].
Nihon Ronen Igakkai Zasshi
September 2024
Aim: When elderly people return to their daily lives after inpatient treatment, they may be offered a chance to change the residence to which they are accustomed. The present study clarified the changes in the residence of elderly patients through an Integrated Community Care Ward (ICCW).
Subjects And Methods: Patients were admitted to and discharged from the ICCW (53 beds) of Hospital A, located in a city with a population of 30,000 and an aging rate of 37%, for 2 years from April 1, 2018, to March 31, 2020.
Article Synopsis
- - The study investigates the gene expression profiles of dogs with high-grade B-cell lymphoma who underwent chemotherapy, focusing on those that either relapsed early or achieved remission.
- - Researchers analyzed 25 cases and identified 179 differentially expressed genes (DEGs), highlighting specific genes related to immune signaling and tumor interactions that differed between dogs that relapsed and those that did not.
- - Notably, genes like CCL4 were downregulated in the relapse group, while genes such as CD3E, ITK, and LAT were upregulated, suggesting that tumor and immune cell interactions play a crucial role in the effectiveness of chemotherapy.
The present study aimed to verify the changes in the expression levels of 13 candidate genes associated with chemotherapy resistance and to construct a scoring system to predict resistance to these drugs. The expression levels of the 13 candidate genes were compared between 20 dogs with lymphoma that were sensitive to drugs used in CHOP-based protocol and 16 dogs with lymphoma that were resistant to these drugs. The expression levels of six genes; ASNS, CCR3, CALCA, FCER1A, LOC448801, and EDNRB were significantly different between the two groups.
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- Genetic studies on mtDNA and the Y chromosome have aimed to explore the relationships among three Native American language groups: Amerind, Na-Dene, and Eskimo-Aleut.
- The study also investigated human polyomavirus JC (JCV) to understand its role in these relationships, focusing on a specific subtype, MY, which is found in both Japanese/Koreans and Native Americans.
- Phylogenetic analysis revealed that while Japanese/Korean MY sequences clustered together, Native American MY sequences were more diverse and showed no clear distinction between Amerinds and Na-Denes, despite their linguistic differences.