Publications by authors named "J N van der Pers"
Background: Interpreting biological system changes requires interpreting vast amounts of multi-omics data. While user-friendly tools exist for single-omics analysis, integrating multiple omics still requires bioinformatics expertise, limiting accessibility for the broader scientific community.
Results: BiomiX tackles the bottleneck in high-throughput omics data analysis, enabling efficient and integrated analysis of multiomics data obtained from two cohorts.
Article Synopsis
- Systemic sclerosis (SSc) is a complicated disease with various manifestations, making it hard to manage, but autoantibodies may help identify different patient groups and their underlying mechanisms.
- A study of 206 SSc patients used antibody status (ACA and SCL70) and various biological analyses to explore differences between groups.
- Results showed that SCL70-positive patients had more severe symptoms and unique biological profiles, while ACA-positive patients had a different set of immune and metabolic features, highlighting the importance of serological status in understanding and treating the disease.
The conventional classification of mature B cells overlooks the diversity within IgD CD27 naïve B cells. Here, to identify distinct mature naïve B cells, we categorized CD45RB B cells (NA RB-) and CD45RB B cells (NA RB+) and explore their function and localization in circulation and tissues under physiological and pathological conditions. NA RB+ B cells, found in secondary lymphoid organs, differentiate into plasmablasts and secrete IgM.
View Article and Find Full Text PDFFine mapping and bioinformatic analysis of the genetic risk association in Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chromatin interactions in immune, salivary gland epithelial, and kidney epithelial cells revealed cell type-specific allelic effects for all five SNPs that expanded regulation beyond effects on and expression. Mapping the local chromatin regulatory network revealed several additional genes of interest, including .
View Article and Find Full Text PDFObjective: Tissue-resident memory cells (Trm) are a subset of T cells residing persistently and long-term within specific tissues that contribute to persistent inflammation and tissue damage. We characterised the phenotype and function of Trm and the role of CD103 in primary Sjogren's syndrome (pSS).
Methods: In both pSS and non-pSS sicca syndrome patients, we examined Trm frequency, cytokine production in salivary glands (SG) and peripheral blood (PB).