High-Resolution Proteomics Unveils Salivary Gland Disruption and Saliva-Hemolymph Protein Exchange in -Infected Mosquitoes.

sporozoites, the stage that initiates a malaria infection, must invade the mosquito salivary glands (SGs) before transmitting to a vertebrate host. However, the effects of sporozoite invasion on salivary gland physiology and saliva composition remain largely unexplored. We examined the impact of infection on salivary glands using high-resolution proteomics, gene expression, and morphological analysis.

A deep insight into the sialome of the house fly, Musca domestica, infected with the salivary gland hypertrophy virus (MdSGHV).

The house fly, Musca domestica, serves as a mechanical vector for numerous pathogens, posing a significant risk to human and animal health. More than two decades ago, the Musca domestica salivary gland hypertrophy virus (MdSGHV) was discovered, infecting both males and females flies and disrupting mating and the reproductive process. While MdSGHV can infect various tissues, its primary replication site is the house fly salivary gland.

Evaluation of the Performance of a Dengue NS1 Assay During the 2024 Epidemic in Brazil.

Accurate diagnosis of dengue in the acute phase is crucial for proper patient management, reducing mortality rates, and enabling public health authorities to implement effective vector control measures. Our study, conducted during the 2024 dengue epidemic in Brazil, compared the results of a rapid dengue NS1 antigen detection assay with dengue RT-PCR using 300 serum specimens. Ninety-five percent of the patients reported symptoms consistent with dengue infection.

An Under-Recognised Rapidly Fatal Condition: Phlegmonous Gastritis.

Unlabelled: Phlegmonous gastritis is a rare condition, characterised by an infectious process in the gastric wall. There is an association with haemolytic infection in approximately 70% of cases, less frequently with other infectious agents such as , and . Diagnosis is often delayed due to non-specific symptoms, such as abdominal pain, nausea, vomiting and fever.

Real time automatic risk prediction in ICU patients treated with ECMO.

The COVID-19 pandemic has underscored the relevance of intensive care medicine. ICUs faced repeated strain, relying on advanced equipment for care provision. ECMO emerged as pivotal, providing support to patients lacking sufficient oxygen delivery via invasive mechanical ventilation.