Publications by authors named "J N Poynter"
Factors driving accelerated biological age (BA), an important predictor of chronic diseases, remain poorly understood. This study focuses on the impact of diet and gut microbiome on accelerated BA. Accelerated Klemera-Doubal biological age (KDM-BA) was estimated as the difference between KDM-BA and chronological age.
View Article and Find Full Text PDFComparison of overall and patterns of care in patients with a malignant ovarian germ cell tumor by age in the United States: a National Cancer Database (2004-2016) analysis.
Int J Gynecol Cancer
December 2024
Article Synopsis
- Women aged 40 years and older diagnosed with malignant ovarian germ cell tumors experience poorer outcomes compared to younger patients (15-39 years), reflecting higher risks and severity of their conditions.
- The study utilized the National Cancer Database from 2004-2016 to analyze care patterns and survival rates across different age groups, focusing on four common tumor types.
- Results indicated older women were more likely to face additional health issues, advanced disease stages, and less effective treatments, contributing to a significantly higher risk of death from their diagnosis.
Remote Field Application of Digital Technology for Hearing Assessments in a Cohort of Pediatric Germ Cell Tumor Survivors.
Cancer Epidemiol Biomarkers Prev
September 2024
Background: Childhood cancer survivors treated with platinum-based chemotherapy are at risk of treatment-induced hearing loss. Accurate evaluation of hearing thresholds has historically been limited to clinical audiometry, which is logistically challenging and expensive to include in epidemiologic studies. We evaluated the feasibility of using a remote, tablet-based hearing assessment in a cohort of pediatric germ cell tumor survivors treated with platinum-based chemotherapy.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the relationship between tea and coffee consumption and the incidence of biliary tract cancer (BTC) using data from 15 studies.
- Drinking tea was linked to a lower risk of gallbladder cancer (GBC) and possibly intrahepatic bile duct cancer (IHBDC), while coffee consumption was associated with a higher risk of GBC.
- The findings suggest that tea might be protective against certain types of BTC, whereas coffee could increase the risk of GBC, warranting further investigation into these associations.
Innovations in the care of adolescent and young adult (AYA) germ cell tumors (GCTs) are needed for one of the most common AYA cancers for which treatment has not significantly changed for several decades. Testicular GCTs (TGCTs) are the most common cancers in 15- to 39-year-old men, and ovarian GCTs (OvGCTs) are the leading gynecologic malignancies in women younger than 25 years. Excellent outcomes, even in widely metastatic disease using cisplatin-based chemotherapy, can be achieved since Einhorn and Donohue's landmark 1977 study in TGCT.
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