Publications by authors named "J N Poston"
Rapid accumulation of knowledge and skills by trainees in the intensive care unit assumes prior mastery of clinically relevant core physiology concepts. However, for many fellows, their foundational physiology knowledge was acquired years earlier during their preclinical medical curricula and variably reinforced during the remainder of their undergraduate and graduate medical training. We sought to assess the retention of clinically relevant pulmonary physiology knowledge among pulmonary and critical care medicine (PCCM) and critical care medicine (CCM) fellows.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied people with low blood platelets who might bleed more easily, even when they got extra platelets.
- They found that 46% of the 330 participants experienced significant bleeding, with similar results for those taking medicine and those who didn’t.
- The research showed that having very low platelets and low red blood cells increased the risk of bleeding, suggesting that doctors might need to help raise red blood cell levels to prevent this.
Acquired hemophilia A (AHA) is an autoimmune bleeding disorder that is caused by factor VIII (FVIII) autoantibodies with high morbidity and mortality due to bleeding and complications from immunosuppression (IST). To address the real-world implications of the FVIII mimetic antibody, emicizumab, and the role of IST, we retrospectively collected de-identified data on 62 patients with AHA who were treated off-label with emicizumab for a median of 10 weeks at 12 US-based hemophilia treatment centers. Most patients (95.
View Article and Find Full Text PDFFewer severe infections with tranexamic acid in patients with hematologic malignancies.
Res Pract Thromb Haemost
February 2024
Background: Tranexamic acid (TXA) is an antifibrinolytic agent that reduces bleeding in a multitude of clinical settings from postpartum hemorrhage to trauma. TXA may have clinical effects unrelated to bleeding; plasminogen, the target of TXA, alters immune responses, and TXA appears to decrease the risk of infection in patients undergoing cardiac surgery, as well as joint arthroplasty.
Objectives: To address whether TXA alters rates of infection and inflammatory outcomes in patients with hematologic malignancies.