Human Milk Oligosaccharides and Lactose Differentially Affect Infant Gut Microbiota and Intestinal Barrier In Vitro.

Background: The infant gut microbiota establishes during a critical window of opportunity when metabolic and immune functions are highly susceptible to environmental changes, such as diet. Human milk oligosaccharides (HMOs) for instance are suggested to be beneficial for infant health and gut microbiota. Infant formulas supplemented with the HMOs 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) reduce infant morbidity and medication use and promote beneficial bacteria in the infant gut ecosystem.

Facilitating Factors in the Proper Identification of Acute Skin Failure: A Systematic Review.

Background: Acute skin failure is a significant medical finding for both the critical care patient and the hospital. Proper identification is key to prevention and treatment, but diagnosis of acute skin failure in critical care patients is often missed. This diagnostic oversight may be due to a lack of knowledge about acute skin failure and its presentation.

Changes to a Shift Reporting Sheet on a Critical Care Unit-Nurse Perceptions and Lessons Learned.

Purpose: Improved perception and compliance with timely completion of the shift summary tool by bedside critical care nurses, and standardization of reported patient condition and treatment variables can be accomplished through collaboration and evidence-based modifications.

Materials And Methods: The IOWA Model was used as a framework to implement change in the population of practicing bedside nurses. In accordance with the AACN Healthy Work Environment standards, the population was given opportunity to complete surveys on a Likert scale to construct a best-fit instrument specific to the nurses' home units.

Blends of Human Milk Oligosaccharides Confer Intestinal Epithelial Barrier Protection in Vitro.

Breastfeeding is integral in the proper maturation of the intestinal barrier and protection against inflammatory diseases. When human milk (HM) is not available, supplementation with HM bioactives like Human Milk Oligosaccharides (HMOs) may help in providing breastfeeding barrier-protective benefits. An increasing HMO variety is becoming industrially available, enabling approaching the HMO complexity in HM.

Enterobacteriaceae are essential for the modulation of colitis severity by fungi.

Background: Host-microbe balance maintains intestinal homeostasis and strongly influences inflammatory conditions such as inflammatory bowel diseases (IBD). Here we focused on bacteria-fungi interactions and their implications on intestinal inflammation, a poorly understood area.

Methods: Dextran sodium sulfate (DSS)-induced colitis was assessed in mice treated with vancomycin (targeting gram-positive bacteria) or colistin (targeting Enterobacteriaceae) and supplemented with either Saccharomyces boulardii CNCM I-745 or Candida albicans.