Is Brief Admission Effective for Individuals With Lived Experience of Borderline Personality Disorder (BPD) When Experiencing Crisis? A Mixed Systematic Review.

Brief admission has been widely used to support individuals with lived experience of borderline personality disorder (BPD) who are experiencing crisis. This study updates a previous 2014 systematic review of the effectiveness of brief admission for individuals with BPD. Following PRISMA guidelines, four databases (MEDLINE, CINAHL, PsychINFO and Cochrane library) were searched from 2011.

Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) tumors are deficient in glutamine, an amino acid that tumor cells and CAFs use to sustain their fitness. In PDAC, both cell types stimulate macropinocytosis as an adaptive response to glutamine depletion. CAFs play a critical role in sculpting the tumor microenvironment, yet how adaptations to metabolic stress impact the stromal architecture remains elusive.

Evaluating the research capacity and culture of an urban Mental Health and Wellbeing Program.

ObjectiveResearch capacity in health care involves the ability to conduct, access, evaluate, and apply research evidence and results in elevated quality of care. Despite its significance, mental health organisations face challenges in assessing and enhancing their research capacity. This study aimed to evaluate the research capacity and culture within a large metropolitan health service's Mental Health and Wellbeing Program (MHWP).

Understanding Why People Experiencing a Mental Health Crisis Leave the Emergency Department Before Care: A Qualitative Interpretive Study.

A number of people experiencing a mental health crisis who present to a hospital emergency department (ED) do not wait (DNW) for assessment or care and leave. This phenomenon is poorly understood and offers an opportunity to enhance quality of care. We sought to understand the characteristics and reasons of those who DNW for assessment or care, and what happens after leaving the ED.

Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages.

Technologies that can record neural activity at cellular resolution at multiple spatial and temporal scales are typically much larger than the animals that are being recorded from and are thus limited to recording from head-fixed subjects. Here we have engineered robotic neural recording devices-'cranial exoskeletons'-that assist mice in maneuvering recording headstages that are orders of magnitude larger and heavier than the mice, while they navigate physical behavioral environments. We discovered optimal controller parameters that enable mice to locomote at physiologically realistic velocities while maintaining natural walking gaits.