Biopreservation and reversal of oxidative injury during blood storage by a novel curcumin-based gel formulation.

Blood storage lesion induces cytosolic and membrane changes driven in part by hemoglobin (Hb) oxidation reactions within red blood cells (RBCs). A novel gel formulation containing the antioxidant curcuminoids in a biocompatible solvent system was used to deliver curcumin into RBCs. Incubation of peroxide treated RBCs stored in PBS with curcumin gel led to a reduction in prooxidant ferrylHb and recovery in ATP.

Gender and geographical bias in the editorial decision-making process of biomedical journals: a case-control study.

Objectives: To assess whether the gender (primary) and geographical affiliation (post-hoc) of the first and/or last authors are associated with publication decisions after peer review.

Design: Case-control study.

Setting: Biomedical journals.

Functionally conserved inner mitochondrial membrane proteins CCDC51 and Mdm33 demarcate a subset of fission events.

While extensive work has examined the mechanisms of mitochondrial fission, it remains unclear whether internal mitochondrial proteins in metazoans play a direct role in the process. Previously, the yeast inner membrane protein Mdm33 was shown to be required for normal mitochondrial morphology and has been hypothesized to be involved in mitochondrial fission. However, it is unknown whether Mdm33 plays a direct role, and it is not thought to have a mammalian homolog.

Intraspecific variation in seed dispersal between annual and perennial populations.

Background And Aims: Seed dispersal impacts plant fitness by shaping the habitat and distribution of offspring, influencing population dynamics and spatial genetic diversity. Whether the evolution of dispersal strategies varies across herbaceous life forms (annual, perennial, clonal) is inconclusive. This study examines how seed dispersal strategies vary between annual and perennial populations of Mimulus guttatus (syn.

Implementing genomic newborn screening as an effective public health intervention: sidestepping the hype and criticism.

Genome-wide sequencing of the DNA that can be obtained from a newborn screening blood spot could provide predictions of thousands of genetic diseases that are not currently included in universal newborn screening. Most of the serious ethical, legal, privacy, and social concerns raised by genome sequencing of all infants can be avoided by implementing genomic newborn screening in accordance with widely-accepted public health criteria.