Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice.

Lipid phosphate phosphatase 3 (LPP3) is a membrane-bound enzyme that hydrolyzes lipid phosphates including the bioactive lipid, lysophosphatidic acid (LPA). Elevated circulating LPA production and cellular LPA signaling are implicated in obesity-induced metabolic and cardiac dysfunction. Deletion of LPP3 in the cardiomyocyte increases circulating LPA levels and causes heart failure and mitochondrial dysfunction in mice.

Transthoracic Repair of Giant Paraesophageal and Hiatal Hernias: A Systematic Review and Meta-Analysis.

The utilization of transthoracic approaches for the repair of large hiatus hernias remains a topic of clinical debate. This study aims to evaluate the efficacy, safety, and recovery metrics for transthoracic hiatal hernia repair. A literature search was conducted using the key terms "hiatus hernia," "thoracotomy," "thoracic approach," and "Belsey Mark IV.

Orifice barrier preferences for coronal restoration of root filled teeth by endodontists and other dental practitioners in Australia: A questionnaire survey.

Objectives: To compare the use of orifice barriers (OB) in root-filled teeth (RFT) between specialist endodontic practitioners (SEP) and general and other specialist practitioners (GDP+), and identify common materials, reasons for selection, and techniques.

Methods: An online survey was distributed to SEP and GDP+ practising in Australia. Demographic and multiple-choice questions relating to material selection and technique choices were asked to evaluate and relate usage patterns to practising and training backgrounds.

Hospital Provider's Perspectives on MOUD Initiation and Continuation After Inpatient Discharge.

Background: Individuals with opioid use disorder have high rates of hospital admissions, which represent a critical opportunity to engage patients and initiate medications for opioid use disorder (MOUD). However, few patients receive MOUD and, even if MOUD is initiated in the hospital, patients may encounter barriers to continuing MOUD in the community.

Objective: Describe hospital providers' experiences and perspectives to inform initiatives and policies that support hospital-based MOUD initiation and continuation in community treatment programs.

Enhancing Healthcare Professionals' Culinary Skills, Food Management, Counseling Confidence, and Mediterranean Diet Adherence Through a Culinary Medicine Boot Camp: A Pilot Implementation Program (PIP).

Awareness of nutrition's role in chronic diseases is rising, demanding guidance on the diet-disease relationship. Nutritional practices become crucial for prevention, prompting healthcare professionals (HCP) to respond. The present study assessed a Culinary Medicine (CM) program's impact on HCP's Mediterranean diet adherence, food and diet therapy knowledge, food management skills, culinary proficiency, and counseling confidence.