Publications by authors named "J N DENT"
Rocatinlimab Improves Patient-Reported Outcomes in Adults with Moderate-to-Severe Atopic Dermatitis: Results from a Double-Blind Placebo-Controlled Phase 2b Study.
Dermatol Ther (Heidelb)
December 2024
Introduction: In adults with moderate-to-severe atopic dermatitis (AD), rocatinlimab demonstrated significant and progressive improvement in clinical measures of disease severity compared with placebo. This post hoc analysis of a phase 2b study was undertaken to understand the disease burden and to assess the impact of rocatinlimab on patient-reported outcomes (PROs).
Methods: This analysis used baseline data from a multicenter, randomized, double-blind study of adults with moderate-to-severe AD, who completed a Worst Pruritus numerical rating scale (NRS), Sleep Disturbance NRS, and the Dermatology Life Quality Index (DLQI).
Article Synopsis
- X-linked hypophosphatemia (XLH) is a genetic disorder that leads to significant skeletal issues and impacts physical function and work productivity in adults.
- A study analyzed data from 281 XLH patients, revealing that many are not employed or rely on disability payments; those with fewer orthopedic surgeries and better physical function are more likely to have full-time jobs.
- Overall, the findings indicate that XLH severely affects work productivity, with younger patients, worse pain, and higher orthopedic surgery counts linked to more demanding job roles.
Article Synopsis
- - Mycosis fungoides (MF) and Sézary syndrome (SS) are skin-related lymphomas that can significantly affect quality of life (HRQL), and a study found that patients treated with mogamulizumab reported better HRQL compared to those on vorinostat.
- - A study involving 372 adults with relapsed MF or SS revealed that their HRQL was notably lower than normal averages, particularly affecting their emotional state and functioning due to factors like itchiness and overall health.
- - Key demographic factors such as being female, younger, and having specific health conditions were linked to worse HRQL across different assessments, emphasizing the need to address these issues in patient care.
Background: Digital health interventions show promise for weight management. However, few text-based behavior change interventions have been designed to support patients receiving intragastric balloons, and none have simultaneously evaluated weight loss, psychological well-being, and behavior change despite the crucial interplay of these factors in weight management.
Objective: This study aims to assess whether a health coach-led, asynchronous, text-based digital behavior change coaching intervention (DBCCI) delivered to participants receiving an intragastric balloon and its aftercare program was feasible and acceptable to participants and supported improved outcomes, including weight loss, psychological well-being, and lifestyle behavior change conducive to weight loss maintenance.
The quartification model is an SU(3)4 extension with a bi-fundamental fermion sector of the well-known SU(3)3 bi-fundamentalfication model. An alternative "flipped" version of the quartification model is obtained by rearrangement of the particle assignments. The flipped model has two standard (bi-fundamentalfication) families and one flipped quartification family.
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