Publications by authors named "J N Crawley"

Rock climbing is a growing sport at both professional and recreational levels. Rock climbing requires specific hand positions with high force outputs to adapt to changing terrain requirements. The purpose of this study was to explore associations between years of climbing experience, the frequency of training, and skill level on force production in 2 different climbing-specific hand positions.

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The G haplotype is a group of co-inherited single nucleotide variants in the F5 gene that reduce venous thromboembolism (VTE) risk. Although 7% of the population is homozygous for the G haplotype (F5-G/G), the underlying mechanism of VTE protection is poorly understood. Using RNA sequencing data from 4651 blood donors in the INTERVAL study, we detected a rare excision event at the factor V (FV)-short splice sites in 5% of F5-G/Gs carriers as compared with 2.

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Article Synopsis
  • There are two types of tissue factor pathway inhibitor (TFPI) in humans: TFPIα and TFPIβ, which help control blood clotting.
  • TFPIα does several important things, including stopping certain proteins that trigger blood clots, while TFPIβ is attached to the surfaces of cells.
  • Recent studies found that TFPIα, working with two other helpers called protein S and FV-short, is really important for controlling bleeding and clotting risks in our blood.
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  • * The design of a new NCI-sponsored randomized trial aims to determine the best chemotherapy regimen for patients who achieve a clinical complete response (cCR) after TNT, potentially allowing for a "watch and wait" strategy instead of immediate surgery.
  • * The trial will enroll up to 760 patients with specific LARC criteria and will evaluate the effectiveness of long-course chemoradiation followed by different consolidation chemotherapy regimens, with patient outcomes being monitored over time.
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Modifying traditional Co/TiO-based Fischer-Tropsch (FT) catalysts with Mn promoters induces a selectivity shift from long-chain paraffins toward commercially desirable alcohols and olefins. In this work, we use gas cell scanning transmission electron microscopy (STEM) with energy-dispersive X-ray spectroscopy (EDS) elemental mapping, and near-ambient pressure X-ray photoelectron spectroscopy (NAP-XPS) to demonstrate how the elemental dispersion and chemical structure of the as-calcined materials evolve during the H activation heat treatment required for industrial CoMn/TiO FT catalysts. We find that Mn additions reduce both the mean Co particle diameter and the size distribution but that the Mn remains dispersed on the support after the activation step.

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