Publications by authors named "J N Chambers"

A 5-year-4-month-old neutered female French bulldog had a brain mass that was surgically excised. Histologically, the tumor consisted of neoplastic oligodendroglial and spindle-shaped cells, and chondroid tissues. Immunohistochemically, oligodendroglial cells were immunopositive for oligodendrocyte transcription factor 2 (OLIG2), 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), platelet-derived growth factor receptor alpha (PDGFRA), vimentin, cluster of differentiation 44 (CD44), and WW domain containing transcription regulator 1 (WWTR1).

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Somatic variants accumulate in non-malignant tissues with age. Functional variants, leading to clonal advantage of hepatocytes, accumulate in the liver of patients with acquired chronic liver disease (CLD). Whether somatic variants are common to CLD from differing etiologies is unknown.

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The ability to arrange brightly fluorescent nanoscale materials into well-defined patterns is critically important in advanced optoelectronic structures. Traditional methods for doing so generally involve depositing different color quantum dot "inks," irradiating reactive (e.g.

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Large cell gastrointestinal lymphoma (LCGIL) is the most common extranodal lymphoma in dogs, but its molecular biological backgrounds have not been clarified. In this study, we comprehensively investigated the gene mutations in LCGIL. Whole exome sequencing analysis using four dogs with LCGIL showed mutations in gene in two dogs.

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Purpose: Brexpiprazole, when administered with antidepressant therapy, may provide additional benefits due to complementary actions on noradrenaline (norepinephrine), serotonin, and dopamine neurotransmitter systems. This review addressed the question: what information can preclinical studies provide on the use of brexpiprazole + antidepressant treatment?

Methods: A systematic literature review was conducted to search for preclinical studies of brexpiprazole + antidepressant therapy that included a behavioral test relating to any psychiatric disorder. Ovid MEDLINE, Ovid Embase, and conference abstracts were searched (January 1, 2011-July 5, 2021).

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