Cardiac Resynchronization Therapy for Pacing-Related Dysfunction Post Cardiac Surgery in Neonates.

An infant with DiGeorge syndrome, multiple comorbidities, and truncus arteriosus type II underwent repair complicated by heart block necessitating placement of a dual-chamber bipolar pacing system with right ventricular leads and subsequent resynchronization with placement of left ventricular apical pacing leads. Resynchronization therapy improved QRS duration from 180 ms to 100 ms and ejection fraction from 25% to 54% over the course of 4 weeks with gradual return to normal function and eventual discharge.

Public Health.

Background: Multi-domain initiatives which target modifiable, lifestyle-associated, dementia risk factors are promising tools for dementia prevention. However, those at greatest risk of preventable dementia likely have the least capacity to enact change. Interventions may improve outcomes for those most vulnerable by looking up-stream.

Ultra-sensitive, tumor-informed ctDNA profiling in pembrolizumab-treated esophagogastric cancer patients predicts clinical responses.

To explore whether ultra-sensitive circulating tumor DNA (ctDNA) profiling enables early prediction of treatment response and early detection of disease progression, we applied NeXT Personal, an ultra-sensitive bespoke tumor-informed liquid biopsy platform, to profile tumor samples from the KeyLargo study, a phase II trial in which metastatic esophagogastric cancer (mEGC) patients received capecitabine, oxaliplatin, and pembrolizumab. All 25 patients evaluated were ctDNA-positive at baseline. Minimal residual disease (MRD) events varied from 406,067 down to 1.

A Needs Assessment of Labor and Delivery Nurses Performing NRP in the Delivery Room.

Introduction: Labor and delivery (L&D) nurses are often responsible for initiating the critical first steps of the Neonatal Resuscitation Program (NRP). Identification of knowledge gaps and underlying reasons for NRP non-adherence is crucial for designing educational interventions.

Methods: A convenience sample of 37 L&D nurses from two delivery hospitals were enrolled.

Scleromyxedema and Breast-Implant Associated Lymphoma: Investigating an Unusual Clinical Association.

Scleromyxedema, a rare skin condition, is characterized by a waxy-appearing papular eruption that tends to impact middle-aged adults. Scleromyxedema is often linked to monoclonal gammopathies. However, some patients do not have a coinciding monoclonal gammopathy and experience an atypical presentation of the disease.