Publications by authors named "J N Boletis"
Article Synopsis
- The study investigates how common hypothalamic-pituitary-adrenal (HPA) axis suppression is among kidney transplant recipients (KTRs) on low doses of glucocorticoids, highlighting that 27.5% had low cortisol levels.* -
- It found that KTRs with low cortisol levels tended to be older and longer post-transplant, with cortisol levels positively correlating with other hormones like ACTH and DHEAS.* -
- Despite increased HPA axis suppression in these patients, the study concluded that it was not linked to metabolic disorders like hypertension or diabetes, suggesting ACTH could be a useful biomarker for monitoring HPA activity.*
Objectives: The optimal duration of immunosuppressive (IS) treatment for lupus nephritis (LN) remains uncertain. We assessed the prevalence and predictors of IS tapering and discontinuation (D/C) in LN patients.
Methods: Data from 137 inception cohort LN patients were analyzed.
Acute kidney injury is a common complication following cardiac surgery (CSA-AKI). Serum creatinine levels require a minimum of 24-48 h to indicate renal injury. Nevertheless, early diagnosis remains critical for improving patient outcomes.
View Article and Find Full Text PDFAutosomal Dominant Polycystic Kidney Disease (ADPKD) stands as the most prevalent hereditary renal disorder in humans, ultimately culminating in end-stage kidney disease. Animal models carrying mutations associated with polycystic kidney disease have played an important role in the advancement of ADPKD research. The rat model, carrying an R823W mutation in the gene, is characterized by cyst formation and kidney enlargement.
View Article and Find Full Text PDFIn our prospective, unicenter cohort study, we collected blood samples from 30 newly kidney transplanted patients, at month 1, 2, 3, and 5 for dd-cfDNA analysis, along with creatinine/eGFR and DSA monitoring, and from 32 patients who underwent an indication biopsy and whose dd-cfDNA levels were measured at the time of biopsy and 1 month afterwards. Fourteen of 32 (43.8%) patients in the biopsy group were diagnosed with TCMR and 5 of 32 (15.
View Article and Find Full Text PDF