Cerebral Protection Devices in Case of Left Sided Intracardiac Thrombus: A Multicentre Experience From the Cath Lab and EP Lab.

Background: Performing a left atrial appendage occlusion (LAAO) or catheter ablation with left-sided intracardiac thrombus is considered very-high risk for periinterventional stroke. Cerebral embolic protection (CEP) devices are designed to prevent cardioembolic stroke and have been widely studied in TAVR procedures. However, their role in LAAO and catheter ablation of ventricular tachycardia (VT) or in pulmonary vein isolation (PVI) with cardiac thrombus present remains unknown.

Working with conference planners for maximum efficiency.

Successful conferences are more likely to occur when presenters actively collaborate with conference planners. Although no "best practices" were found, we share our experiences and recommendations to support this collaborative relationship. We emphasize timely communication and preparedness.

The WellNext Scan: Validity evidence of a new team-based tool to map and support physicians' well-being in the clinical working context.

Occupational well-being is inherent to physicians' professional performance and is indispensable for a cost-effective, robust healthcare system and excellent patient outcomes. Increasing numbers of physicians with symptoms of burnout, depression, and other health issues are demonstrating the need to foster and maintain physicians' well-being. Assessing physicians' well-being, occupational demands, and resources can help create more supportive and health-promoting working environments.

Persistent functional and taxonomic groups dominate an 8,000-year sedimentary sequence from Lake Cadagno, Switzerland.

Most of our knowledge of deep sedimentary life comes from marine environments; however, despite their relatively small volume, lacustrine sediments constitute one of the largest global carbon sinks and their deep sediments are largely unexplored. Here, we reconstruct the microbial functional and taxonomic composition of an 8,000-year Holocene sedimentary succession from meromictic Lake Cadagno (Switzerland) using shotgun metagenomics and 16S rRNA gene amplicon sequencing. While younger sediments (<1,000 years) are dominated by typical anaerobic surface sedimentary bacterial taxa (, and , older layers with lower organic matter concentrations and reduced terminal electron acceptor availability are dominated by taxa previously identified as "persistent populations" within deep anoxic marine sediments ( Bathyarchaeia, , and ).