Publications by authors named "J N Bair"
Purinergic agonists increase [Ca] in rat conjunctival goblet cells through ryanodine receptor type 3.
Am J Physiol Cell Physiol
September 2024
ATP and benzoylbenzoyl-ATP (BzATP) increase free cytosolic Ca concentration ([Ca]) in conjunctival goblet cells (CGCs) resulting in mucin secretion. The purpose of this study was to investigate the source of the Ca mobilized by ATP and BzATP. First-passage cultured rat CGCs were incubated with Fura-2/AM, and [Ca] was measured under several conditions with ATP and BzATP stimulation.
View Article and Find Full Text PDFSepsis care delivery-including the initiation of prompt, appropriate antimicrobials-remains suboptimal. This study was conducted to determine direct and off-target effects of emergency department (ED) sepsis care reorganization. This pragmatic pilot trial enrolled adult patients who presented from November 2019 to February 2021 to an ED in Utah before and after implementation of a multimodal, team-based "Code Sepsis" protocol.
View Article and Find Full Text PDFArticle Synopsis
- Cryptococcus neoformans is a fungus that primarily affects individuals with weakened immune systems, often leading to meningoencephalitis, but cases of muscle infections are rare.
- A 45-year-old man with extensive cryptococcal infection developed multiple muscle abscesses and osteomyelitis, which led to surgery, an amputation, and ultimately death.
- Increased awareness and rapid diagnosis of orthopedic complications from cryptococcal infections may enhance patient outcomes.
Background: There is not a preferred medication for treating refractory status epilepticus (RSE) and intravenous ketamine is increasingly used. Ketamine efficacy, safety, dosage, and influence of other variables on seizure cessation while on ketamine infusions are not well studied. We aimed to characterize ketamine effect on RSE, including interictal activity on electroencephalogram (EEG) and when done by Teleneurocritical care (TNCC).
View Article and Find Full Text PDFBackground: Hip fractures constitute a major public health problem for older individuals. They are associated with functional deterioration, limited mobility, and increased mortality, while contributing to economic and social hardships that are compounded by a second hip fracture. With the aging US population and increasing rates of hip fractures, it is essential to understand factors surrounding subsequent contralateral hip fractures.
View Article and Find Full Text PDF