Publications by authors named "J Mysore"
Article Synopsis
- Huntington's disease (HD) is caused by a CAG repeat expansion and is part of a group of disorders linked to unstable short tandem repeats, highlighting the complexity of genetic influences on the disease.
- Research indicates that both overlapping and unique genetic modifiers affect clinical symptoms and somatic expansion in blood DNA, pointing to specific cell-type interactions in mismatch repair processes.
- The study identifies a 5'-UTR variant that causes somatic expansion without altering clinical HD, and a specific sequence change that accelerates motor symptom onset without increasing expansion, emphasizing potential therapeutic targets for managing HD.
Article Synopsis
- A study investigated if continuous infusion of β-lactam antibiotics reduces death risk in critically ill sepsis patients, comparing this method to intermittent infusion.
- Conducted in 104 ICUs across several countries from 2018 to 2023, the trial involved over 7,200 participants receiving either piperacillin-tazobactam or meropenem.
- Results showed a slight decrease in 90-day mortality for continuous infusion (24.9%) versus intermittent infusion (26.8%), but the difference was not statistically significant (-1.9% difference).
Introduction: Cosmetic gynecology is an expanding field with a steep rise in awareness and demand for procedures to enhance the aesthetic appearance of female genitalia.
Aim: This article aims to provide an overview of aesthetic gynecology for a practicing dermatologist.
Methods: A study conducted in India showed a rising trend in the demand of aesthetic vaginal procedures from 3.
Article Synopsis
- The study aimed to evaluate whether selective decontamination of the digestive tract (SDD) lowers in-hospital mortality in critically ill adults.
- A total of 5,982 mechanically ventilated patients from 19 ICUs in Australia participated in a randomized trial contrasting SDD treatment with standard care over two alternating 12-month periods.
- Results showed no significant difference in in-hospital mortality rates between the two groups, with 27% deaths in the SDD group versus 29% in the control, indicating that SDD may not have a substantial impact on mortality.
Genome-wide association studies (GWASs) of Huntington disease (HD) have identified six DNA maintenance gene loci (among others) as modifiers and implicated a two step-mechanism of pathogenesis: somatic instability of the causative HTT CAG repeat with subsequent triggering of neuronal damage. The largest studies have been limited to HD individuals with a rater-estimated age at motor onset. To capitalize on the wealth of phenotypic data in several large HD natural history studies, we have performed algorithmic prediction by using common motor and cognitive measures to predict age at other disease landmarks as additional phenotypes for GWASs.
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