Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death.

Guanine-quadruplex (G4) selective photosensitizers have huge potential for photodynamic therapy against various diseases correlated with G4 DNA and G4 RNAs; however, the types of photosensitizer skeletons available are limited. Herein, we investigated the ability of our original G4 ligands, tripodal quinone-cyanine dyes (tpQCy(s)), which were developed as fluorescent probes for G4, to act as photosensitizers for cancer-selective apoptosis inducers. The results indicated that the tpQCy skeleton has great potential for developing G4-targeted cancer-selective photosensitizers for photodynamic therapy.

Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift.

To visualize the guanine-quadruplex (G4) nucleic acids in cells or in biological tissues, near-infrared (NIR) fluorescent probes that can respond specifically to G4 nucleic acids are required. Herein, an NIR fluorescence switch-on probe for G4 imaging having higher selectivity and extremely large Stokes shift (ca. 220 nm) was successfully developed by the modification of our original tripodal quinone-cyanine fluorescent dye.

Real-Time Observation of Charge-Spin Cooperative Dynamics Driven by a Nonequilibrium Phonon Environment.

We report on experimental observations of charge-spin cooperative dynamics of two-electron states in a GaAs double quantum dot located in a nonequilibrium phonon environment. When the phonon energy exceeds the lowest excitation energy in the quantum dot, the spin-flip rate of a single electron strongly enhances. In addition, originated from the spatial gradient of phonon density between the dots, the parallel spin states become more probable than the antiparallel ones.

Nitrogen mineralization from organic fertilizers and composts: Literature survey and model fitting.

Organic fertilizers and composts are valuable sources of nutrients. However, their nutrient availability is often not known and can be variable. The objective of the present study was to collect net nitrogen (N) turnover data from peer-reviewed articles and fit a model that simulates gross N mineralization and gross N immobilization to determine pool sizes and their rate constants of different common organic amendments.

Analysis of Environmental Variables and Carbon Input on Soil Microbiome, Metabolome and Disease Control Efficacy in Strawberry Attributable to Anaerobic Soil Disinfestation.

Charcoal rot and Fusarium wilt, caused by and f. sp. , respectively, are major soil-borne diseases of strawberry that have caused significant crop losses in California.