Publications by authors named "J Mundy"
Background: Previous research has shown that females who use hormonal contraception are at increased risk of developing depression, and that the risk is highest among adolescents. While this finding could reflect age-specific effects of exogenous hormones on mental health, genetic liability for mental disorders could be confounding the association. Our goal was to test the plausibility of this hypothesis by determining whether polygenic liabilities for major depressive disorder (MDD), bipolar disorder (BD), schizophrenia (SCZ), and attention deficit hyperactivity disorder (ADHD) are associated with younger age at hormonal contraception initiation.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how genetic factors (polygenic scores or PGS) for psychiatric disorders affect the treatment trajectories of individuals with early-onset Major Depressive Disorder (MDD) in secondary care.
- Researchers used data from a large Danish sample, analyzing 10,577 individuals diagnosed with MDD between ages 10-25 to identify different patterns of treatment over seven years.
- Findings reveal specific associations between PGS for ADHD and anorexia with treatment trajectories, suggesting that while genetics may influence the path of depression treatment, the effects are small and not currently useful for predicting clinical outcomes.
Fluoride-ion batteries have several potential advantages over lithium-ion batteries. Materials development is still needed, however, to realize electrolytes with sufficiently high anion conductivity and compatibility with anode and cathode layers. Fluoride compounds are difficult to synthesize directly as single crystals but can be realized from oxide film precursors via topotactic chemistry techniques.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the impact of hydrogen incorporation in layered superconducting nickelate films and its potential link to superconductivity.
- Films are created by converting a stable parent compound into the desired phase using a reducing agent like CaH, but achieving highly crystalline nickelate films remains challenging.
- Findings show that hydrogen incorporation is minimal across various samples, both superconducting and non-superconducting, suggesting that it’s not essential for achieving superconductivity in these nickelate systems.