Publications by authors named "J Moy"
Article Synopsis
- Mycobacteria manage their mRNA stability to adapt to environmental stresses, but the specific mechanisms for this regulation aren't well understood.
- In a study, the researchers measured the half-lives of mRNA across different growth conditions and found that hypoxia led to increased global stabilization of transcripts, especially for essential genes.
- They also created machine learning models to analyze the impact of various transcript properties on stability, revealing that these properties differ based on growth conditions and whether the transcripts have leaders or not.
Importance: A time-limited trial (TLT) is a collaborative plan among clinicians, patients, and families to use life-sustaining therapy for a defined duration, after which the patient's response informs whether to continue care directed toward recovery or shift the focus toward comfort. TLTs are a promising approach to help navigate uncertainty in critical illness, yet little is known about their current use.
Objectives: To characterize TLT use in patients with acute respiratory failure (ARF).
Purpose: The aim of this study is to prospectively evaluate whether women with copper-containing intrauterine devices (Cu-IUD), currently listed as MR conditional, can safely undergo 3.0 Tesla (3 T) magnetic resonance imaging (MRI).
Methods: 73 women, age 18-54 years old, with a Cu-IUD who were undergoing MRI for any reason were included consecutively.
Endothelial dysfunction is a critical feature of acute respiratory distress syndrome (ARDS) associated with higher disease severity and worse outcomes. Preclinical in vivo models of sepsis and ARDS have failed to yield useful therapies in humans, perhaps due to interspecies differences in inflammatory responses and heterogeneity of human host responses. Use of microphysiological systems (MPS) to investigate lung endothelial function may shed light on underlying mechanisms and targeted treatments for ARDS.
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- Mechanisms behind long COVID are not well understood, but studying immunological responses may help clarify clinical variations among patients.
- Researchers analyzed plasma levels of 42 biomarkers from 101 individuals with long COVID, identifying three distinct inflammatory clusters: limited immune activation, innate immune activation, and systemic immune activation.
- Although these inflammatory clusters did not directly correlate with specific symptoms, they were linked to clinical factors such as age, BMI, and vaccination status, suggesting that immune responses may vary along with these variables.