Publications by authors named "J Motyl"
Article Synopsis
- Alpha-synuclein (α-syn) is a protein in the brain essential for cellular function, but it can misfold and aggregate, leading to dysfunction and cell death.
- The accumulation of misfolded α-syn is linked to several neurodegenerative diseases, known as α-synucleinopathies, including Parkinson's disease and others.
- Recent research suggests that SARS-CoV-2 infection could potentially trigger or worsen these diseases by promoting α-syn misfolding and related neurological symptoms.
Lipid measures are associated with cognitive functioning in multiple sclerosis patients.
Mult Scler Relat Disord
November 2024
Background: An association between lipid measures and cognitive decline in patients with multiple sclerosis (MS) has been suggested.
Objectives: This study aimed to investigate relationships between lipid profile and cognitive performance in a large observational cohort of MS patients.
Materials And Methods: We included 211 patients with 316 available pairs of lipid and cognitive measures performed over follow-up.
Background: Early diagnosis and treatment of patients with multiple sclerosis (MS) are associated with better outcomes; however, diagnostic delays remain a major problem.
Objective: Describe the prevalence, determinants and consequences of delayed diagnoses.
Methods: This single-centre ambispective study analysed 146 adult relapsing-remitting MS patients (2016-2021) for frequency and determinants of diagnostic delays and their associations with clinical, cognitive, imaging and biochemical measures.
Background: Although there is evidence that shows worse cognitive functioning in male patients with multiple sclerosis (MS), the role of brain pathology in this context is under-investigated.
Objective: To investigate sex differences in cognitive performance of MS patients, in the context of brain pathology and disease burden.
Methods: Brain MRI, neurological examination, neuropsychological assessment (Brief International Cognitive Assessment in MS-BICAMS, and Paced Auditory Verbal Learning Test-PASAT), and patient-reported outcome questionnaires were performed/administered in 1052 MS patients.