Publications by authors named "J Mosquera Oses"
Article Synopsis
- The study investigates how serum biomarkers and substance use predict the conversion from major depressive disorder (MDD) to bipolar disorder (BD) in adults.
- The conversion rate from MDD to BD was found to be 12.4%, with higher incidences among women and those with specific educational backgrounds and cocaine use.
- The analysis indicated a notable interaction between nerve growth factor (NGF) levels and cocaine use, suggesting these factors may contribute to the diagnostic conversion and, if untreated, could lead to poorer outcomes in BD prognosis.
The role of metabolic syndrome as a mediator in the relationship between CCL11 levels and the presence of a mood episode with mixed features in young adults with bipolar disorder.
J Psychiatr Res
July 2024
Article Synopsis
- - Mixed features presentation in bipolar disorder (BD) is the most severe form, with increased serum levels of CCL11 contributing to cognitive decline and functional deterioration, a process known as neuroprogression.
- - Metabolic syndrome (MetS) is common in BD and could heighten inflammation and CCL11 levels, potentially worsening mood episodes with mixed features.
- - The study aimed to determine if MetS mediates the relationship between CCL11 levels and mixed mood episodes in BD, finding a trend suggesting MetS may play a significant role in accelerating neuroprogression in affected individuals.
University students frequently resort to psychostimulants to enhance their physical and mental performance and manage academic pressures. However, these substances can lead to dependence and other undesired symptoms, and little empirical data are available for relevant stakeholders, raising significant concerns in health care. Therefore, this study aims to characterize neurostimulant use among university students in Rio Grande do Sul, Brazil.
View Article and Find Full Text PDFDecreasing neurotrophic support and impaired mitochondrial bioenergetics are key mechanisms for long-term neurodegeneration and cognitive decline after traumatic brain injury (TBI). We hypothesize that preconditioning with lower and higher volumes of physical exercise upregulates the CREB-BDNF axis and bioenergetic capability, which might serve as neural reserves against cognitive impairment after severe TBI. Using a running wheel mounted in the home cage, mice were engaged in lower (LV, 48 h free access, and 48 h locked) and higher (HV, daily free access) exercise volumes for thirty days.
View Article and Find Full Text PDFObjective: The current study assesses whether the association between diagnosis of Bipolar Disorder (BD) in mothers and emotional and behavioral problems (EBP) in their offspring is mediated by a disruption in the offspring's biological rhythms.
Methods: A probabilistic sample of 492 public school children (ages 7-8, 48 % female) were assessed for biological rhythms disruption and EBP using the Biological Rhythms Interview for Assessment in Neuropsychiatry for Kids and the Strengths and Difficulties Questionnaire, respectively. Mothers' mental health (BD = 64) was evaluated using a standardized clinical interview.