Publications by authors named "J Morote"
The role of digital rectal examination (DRE) in the early detection of significant prostate cancer (PCa) is being questioned in the era of magnetic resonance imaging (MRI). However, some men with suspected PCa may still be identified solely through DRE, even with low serum prostate-specific antigen (PSA) levels. Additionally, most predictive models designed to improve significant PCa diagnostic pathways incorporate DRE findings.
View Article and Find Full Text PDFConcordance Between the Expert Reading of Biparametric-MRI and the Nonexpert Multiparametric-MRI for the Detection of Clinically Significant Prostate Cancer: Clinical Implications.
Clin Genitourin Cancer
December 2024
Purpose: Prostate-magnetic resonance imaging (MRI) interpretation is challenging, with expertise playing a crucial role. Biparametric MRI (bpMRI) is gaining popularity in experienced centers due to its time and cost advantages over multiparametric MRI (mpMRI). We aim to analyze concordance between nonexpert radiologist PI-RADS from mpMRI and expert radiologist PI-RADS from bpMRI, and its clinical implications.
View Article and Find Full Text PDFEarly detection of clinically significant prostate cancer (csPCa) has substantially improved with the latest PI-RADS versions. However, there is still an overdiagnosis of indolent lesions (iPCa), and radiomics has emerged as a potential solution. The aim of this systematic review is to evaluate the role of handcrafted and deep radiomics in differentiating lesions with csPCa from those with iPCa and benign lesions on prostate MRI assessed with PI-RADS v2 and/or 2.
View Article and Find Full Text PDFArticle Synopsis
- Prostate cancer is a major cause of cancer-related deaths in European men, highlighting the need for better risk assessment tools, particularly focusing on the P72R SNP in the TP53 gene that may increase susceptibility to the disease.
- A study examined the prevalence of the P72R SNP in different prostate cancer samples and found significantly higher rates in cancer patients compared to a non-cancer control group, indicating a strong association with risk of aggressive prostate cancer.
- The findings suggest that the P72R SNP could serve as a valuable marker for identifying individuals at risk for aggressive forms of prostate cancer, paving the way for early intervention and better treatment strategies.
Purpose: To validate the Barcelona magnetic resonance imaging predictive model (BCN-MRI PM) in men with pre-biopsy multiparametric MRI (mpMRI) reported with the Prostate Imaging Reporting and Data System (PI-RADS) v2.1, followed by transrectal and transperineal prostate biopsies.
Materials And Methods: Prospective analysis of 3,264 men with PSA >3.