Background: Increased body mass index (BMI) in mid‐life is associated with a higher risk of Alzheimer’s disease (AD). Neurofibrillary tangles (NFTs), comprised of hyperphosphorylated aggregated tau protein, are the pathological hallmark of neurodegenerative tauopathies including Alzheimer’s Disease (AD). The relationship between sex‐dependent adiposity in late adulthood and tau NFT pathology remain inconclusive.
View Article and Find Full Text PDFBackground: We examined racial differences between measures of limbic white matter tracts and objective sleep parameters in cognitively unimpaired older‐adults.
Method: This cross‐sectional study included 170 community‐dwelling cognitively unimpaired older‐adults (mean±SD: age = 67.2±5.
Background: In the United States, Black people represent 12% of the total US population and account for 19.3% of dementia cases. Social determinants of health (SDOH) and vascular comorbidities contribute to Black/African Americans having a higher risk of Alzheimer’s disease and related dementias (ADRD).
View Article and Find Full Text PDFBest Pract Res Clin Anaesthesiol
September 2024
The issue of obesity continues to reach new levels globally, affecting individuals across the age continuum. Obesity in pregnancy is associated with myriad comorbidities which may negatively impact the fetus, particularly dysfunctional labor and failure to progress ending in unplanned cesarean delivery. Neuraxial anesthesia represents the gold standard for cesarean delivery anesthesia and is increasingly beneficial for obese patients due to the risk of difficult airway.
View Article and Find Full Text PDFPediatric femur fractures often necessitate surgical intervention, with pain management being critical for both immediate and long-term outcomes. Peripheral nerve blocks (PNBs) and neuraxial techniques are effective in providing targeted pain relief while minimizing systemic opioid exposure. Despite their benefits, the utilization of these anesthesia techniques in pediatric orthopedic surgeries is limited, particularly among socioeconomically disadvantaged patients.
View Article and Find Full Text PDF