Publications by authors named "J Montanaro"

Article Synopsis
  • Autoantibodies against LGI1 are linked to autoimmune encephalitis, impacting the limbic system and causing seizures and memory issues.
  • The study focused on how these autoantibodies influence synaptic structure and function, revealing effects on neurotransmitter release.
  • Results showed that LGI1 autoantibodies enhanced neurotransmission by increasing release probability but did not affect presynaptic calcium channels; however, they reduced certain potassium channel densities.
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Background: Pandemics and natural disasters are immensely stressful events for frontline healthcare workers, as they provide patient care to a population undergoing the impacts of the disaster while experiencing such impacts to their personal lives themselves. With increased stressors to an already demanding job, frontline healthcare workers are at a higher risk of adverse effects to their mental health. The current COVID-19 pandemic has already shown to have had significant impact on the mental health of healthcare workers with increased rates of burnout, anxiety and depression.

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Upon the arrival of action potentials at nerve terminals, neurotransmitters are released from synaptic vesicles (SVs) by exocytosis. Ca 2.1, 2.

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The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca channels (Cav2.3) and auxiliary GABA receptor (GBR) subunits, the K-channel tetramerization domain-containing proteins (KCTDs). Activation of GBRs facilitates or inhibits transmitter release from MHb terminals depending on the IPN subnucleus, but the role of KCTDs is unknown.

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Background: Acute respiratory distress syndrome carries a 40% mortality rate. Prone positioning remains underused owing to clinicians' low degree of confidence, concern about the risk of adverse outcomes, and lack of staff competency training.

Local Problem And Purpose: A prone positioning protocol and educational program were needed in an intensive care unit to achieve compliance with best practices for treating acute respiratory distress syndrome patients.

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