Publications by authors named "J Monsonego"
Article Synopsis
- * A review of 19 studies involving over 3,000 cases revealed that HPV-positive cervical intraepithelial neoplasia grade 2 or more (CIN2+) is associated with higher cancer risk indicators compared to HPV-negative cases.
- * HPV-negative CIN2+ cases show a lower risk of progressing to cancer and often have low-risk HPV genotypes; however, adjustments in clinical studies for HPV testing may impact the estimated effectiveness of detecting precancerous conditions.
Objective: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59).
Methods: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods.
Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation.
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