Publications by authors named "J Mollerup"
This Special Issue features contributions from leading international researchers in the field of MET (hepatocyte growth factor (HGF) receptor) biology and therapeutics [...
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- Perseverance's Mastcam-Z captures detailed stereo and multispectral images, offering a comprehensive view of the geology in Jezero crater on Mars.
- The rocks depicted show features indicating they are of igneous or impactite origin, with minimal water alteration and include various mineral compositions like mafic silicates and olivine.
- Additional imaging reveals important atmospheric conditions, including dust variations and unique interactions caused by dust devils and the Ingenuity helicopter, which aid in understanding Mars' environment and assist in rover operations.
Dysregulation of the MET tyrosine kinase receptor is a known oncogenic driver, and multiple genetic alterations can lead to a clinically relevant oncogenesis. Currently, a number of drugs targeting MET are under development as potential therapeutics for different cancer indications, including non-small cell lung cancer (NSCLC). However, relatively few of these drugs have shown sufficient clinical activity and obtained regulatory approval.
View Article and Find Full Text PDFThe development of trastuzumab (Herceptin) was one of the most significant cancer drug development projects of the 20th century. Not only was it a scientific and medical achievement but it also paved the way for the drug-diagnostic codevelopment model, where a predictive biomarker assay is developed in parallel to the drug. One of the challenges in the development of trastuzumab was to select the right patient population likely to respond and here, it was critical to have access to an accurate, robust and reliable assay for detection of HER2 overexpression in tumors.
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