Endogenous ergothioneine is required for wild type levels of conidiogenesis and conidial survival but does not protect against 254 nm UV-induced mutagenesis or kill.

Ergothioneine, a histidine derivative, is concentrated in conidia of ascomycetous fungi. To investigate the function of ergothioneine, we crossed the wild type Neurospora crassa (Egt(+)) and an ergothioneine non-producer (Egt(-), Δegt-1, a knockout in NCU04343.5) and used the Egt(+) and Egt(-) progeny strains for phenotypic analyses.

Deterioration of conjunctival PO2 after CPR.

An 82-year-old man was resuscitated following cardiac arrest suffered outside the hospital. Conjunctival oxygenation (PcjO2), as measured by a conjunctival PO2 monitor, increased in the immediate post-resuscitation period (60 min) and neurologic status improved. The PcjO2 steadily declined over the next three hours.