Publications by authors named "J Moberly"
Article Synopsis
- Research is focused on finding new biologically active compounds, specifically Azothioformamides (ATFs), which can form stable coordination complexes with metals like copper for potential anticancer and antimicrobial therapies.
- In this study, different ATF ligands with varying heterocyclic groups were synthesized and complexed with Cu(I) salts, which were chosen for their potential lower toxicity and effective binding properties.
- The results indicated that smaller pyrrolidine-substituted ATFs showed stronger binding to Cu(I) salts and had varying levels of antimicrobial activity, particularly against some cancer cell lines, while the ATF ligands alone showed limited effectiveness.
Article Synopsis
- Clinoptilolite shows varying effectiveness in capturing and releasing iron based on pH levels, with optimal sorption occurring between pH 2 and 3.5.
- At pH 2, up to 70% of captured iron can be desorbed from a previous pH 3 solution, indicating that iron retention occurs primarily through sorption and exchange processes.
- The study suggests that clinoptilolite can maintain its ability to hold onto metals, even as acidity increases, evolving through different states of metal retention as pH changes.
Article Synopsis
- Rare earth elements (REEs) are important for various industries, and this study focuses on how the bacteria Cupriavidus necator can uptake these elements like europium, samarium, and neodymium.
- The researchers use dielectrophoretic ultra-high-frequency measurements to assess the impact of REEs on the conductivity of C. necator before and after exposure.
- They also created a microfluidic sorter using COMSOL Multiphysics to separate bacteria that absorbed REEs from those that did not, based on their electrical properties.
This work presents the dielectric characterization of rare earth elements (REEs) biosorption by Cupriavidus necator using dielectrophoretic crossover frequency measurements. Traditional means of characterizing biomass for biosorption is limited and time consuming. In this research we are presenting, for the first time, an electrokinetic method termed as dielectrophoresis (DEP) for the characterization of biosorption (uptake) of rare earth elements (REEs) by gram negative bacteria - Cupriavidus necator.
View Article and Find Full Text PDFThe COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus has imposed severe challenges on laboratories in their effort to achieve sufficient diagnostic testing capability for identifying infected individuals. In this study, we report the analytical and clinical performance characteristics of a new, high-throughput, fully automated nucleic acid amplification test system for the detection of SARS-CoV-2. The assay utilizes target capture, transcription-mediated amplification, and acridinium ester-labeled probe chemistry on the automated Panther system to directly amplify and detect two separate target sequences in the open reading frame 1ab (ORF1ab) region of the SARS-CoV-2 RNA genome.
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